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Animal evidence
There is evidence that the endocannabinoid system may influence in nicotine’s reward effects in the brain. Studies of the effects of rimonabant using animal models began in 2001, and data have been obtained regarding the potential utility in nicotine dependence. Cohen et al (2005) studied nicotine-seeking behavior in rats. Rats who were given rimonabant [...]
Pharmacotherapy for tobacco dependence is an important component of a comprehensive treatment plan that includes behavioral interventions and psychosocial support. The primary effects of nicotine are mediated by nicotinic acetylcholine receptors, many subtypes of which are widely distributed throughout the central nervous system. A high concentration of α4 subunits is found in the ventral tegmental [...]
Rimonabant in rats with a metabolic syndrome: good news after the depression
In the industrialized world, the prevalence of obesity has reached epidemic proportions. In the United Kingdom, almost half of the adults will be obese by 2015, and this, the British Medical Journal warns, could bankrupt the National Health Service. Obese people are at high [...]
Clomid (Clomiphene) is used for treating female infertility.
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Clomid information
Drug Name
Clomid (Clomiphene)
Drug Uses
Clomid is used for treating female infertility and for certain conditions as determined by your doctor.
How to use
Use Clomid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Clomid by mouth with or without food.
Properly timed sexual intercourse is important for good results. Ovulation usually occurs 5 to 10 days after a dose of Clomid.
Drug Class and Mechanism
Clomid is an ovulatory stimulant. It works by helping to produce more hormones that cause your ovaries to release 1 or more eggs.
Missed Dose
If you miss a dose of Clomid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage
Store Clomid at 77 degrees F (25 degrees C). Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clomid out of the reach of children and away from pets.
Warnings/Precautions
Do not use Clomid if:
you are allergic to any ingredient in Clomid;
you are pregnant;
you have abnormal vaginal bleeding;
you have ovarian cysts (small growths on the ovaries) or enlargement not due to polycystic ovarian syndrome;
you have or have ever had blockage of blood vessels (blood clots) in the legs, lungs, or other parts of the body;
you have liver problems, uncontrolled thyroid or adrenal gland problems, or a brain lesion (e.g., pituitary gland tumor) .
Contact your doctor or health care provider right away if any of these apply to you.
Important:
Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Enlargement of the ovaries may happen during or shortly after taking Clomid . Call your health care provider if you experience any stomach or pelvic pain, weight gain, pain, or stomach enlargement or discomfort while taking Clomid.
Pregnancy with more than 1 fetus (e.g., twins) is possible while you are taking Clomid . Be sure you have discussed the potential complications and hazards of multiple pregnancy;
Lab tests, including pregnancy tests, may be performed while you use Clomid . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Clomid with caution in the elderly; they may be more sensitive to its effects.
Pregnancy and breast-feeding: do not use Clomid if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Clomid is found in breast milk. Do not breast-feed while taking Clomid.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
blurred vision or vision problems (spots or flashes); breast tenderness; dizziness; enlarged breasts; enlargement of the ovaries; flushing; headache; hot flashes; lightheadedness; mood change; nausea; pelvic pain or bloating; stomach pain; vomiting.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)increased risk of cancer of the ovaries; over stimulation of the ovaries; spontaneous abortion.
More Information
Clomid is to be used only by the patient for whom it is prescribed. Do not share it with other people.